Back to Search
Start Over
EV PD-L1 Contributes to Immunosuppressive CD8 T Cells in Peripheral Blood of Pediatric Wilms Tumor
- Source :
- Technology in Cancer Research & Treatment, Vol 20 (2021)
- Publication Year :
- 2021
- Publisher :
- SAGE Publishing, 2021.
-
Abstract
- Wilms tumor (WT) is the most common renal cancer and the most prevalent abdominal cancer in children. Children with recurrent or progressive forms of WT could benefit from novel immune-targeted approaches. While the immune status of these patients, especially the immunosuppression of peripheral T cells, was rarely reported. The present study enrolled a consecutive series of 14 Chinese WT children and 14 age- and gender-matched healthy controls. We demonstrated that plasma extracellular vesicular (EV) PD-L1 levels significantly increased in WT patients than in healthy controls. EV PD-L1 significantly inhibited the activation of human CD8 + T cells by down-regulating the cell surface CD69 expression and the intracellular IFNγ and TNFα production in vitro. In peripheral CD8 + T cells of WT patients, the intracellular IFNγ and TNFα production significantly decreased than healthy controls. The level of plasma EV PD-L1 significantly correlated with the intracellular TNFα production in peripheral CD8 + T cells of WT patients. In conclusion, the significantly increased plasma EV PD-L1 in WT patients contributed to the immunosuppression of peripheral CD8 + T cells. Monitoring the level of plasma EV PD-L1 will be helpful for the selection of immune-targeted therapies for WT patients.
- Subjects :
- Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 15330338
- Volume :
- 20
- Database :
- Directory of Open Access Journals
- Journal :
- Technology in Cancer Research & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9d8d27d693ea4652b3fa6e08c54e7457
- Document Type :
- article
- Full Text :
- https://doi.org/10.1177/15330338211041264