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Research progress on the mechanism of astragaloside IV in the treatment of asthma

Authors :
Fanyi Yuan
Yang Yang
Li Liu
Pengcheng Zhou
Yi Zhu
Yilu Chai
Keling Chen
Wenjun Tang
Qingsong Huang
Chuantao Zhang
Source :
Heliyon, Vol 9, Iss 11, Pp e22149- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Asthma is a common chronic respiratory disease, and its treatment is a core problem and challenge in clinical practice. Glucocorticoids (GCs) are the first-line therapy for the treatment of asthma. Local and systemic adverse reactions caused by GCs create obstacles to the treatment of asthma. Therefore, the research target is to find a new, safe, and effective therapeutic medicine at present. Natural products are an important source for treating asthma with low cost and low toxicity. Astragaloside IV (AS-IV) is an active ingredient of traditional Chinese medicine Astragalus mongholicus Bunge. Previous studies have indicated that AS-IV plays a therapeutic role in the treatment of asthma by inhibiting airway inflammation and remodeling the airway, and by regulating immunity and neuroendocrine function (Fig. 1) . It has a variety of biological characteristics such as multi-target intervention, high safety, and good curative effect. This article reviews the specific mechanism of AS-IV for the treatment of asthma to provide references for subsequent research.

Details

Language :
English
ISSN :
24058440
Volume :
9
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.9d8194505add46e68237d95463a48f71
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2023.e22149