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Accidental ABO-incompatible pediatric liver transplantation with blood group antigen immune and operational tolerance: a case report with 21 years of follow-up
- Source :
- Korean Journal of Transplantation, Vol 37, Iss 4, Pp 306-309 (2023)
- Publication Year :
- 2023
- Publisher :
- Korean Society for Transplantation, 2023.
-
Abstract
- Liver transplantation is a critical procedure for patients with end-stage liver disease, but it is often hindered by ABO-incompatibility between the donor and recipient, which can lead to immediate humoral rejection. We present a unique case involving a 10-month-old patient who, by accident, received an ABO-incompatible partial liver transplant from a type A mother without undergoing desensitization. Remarkably, during a 21-year follow-up period, the patient exhibited no signs of humoral or graft rejection, despite nonadherence to medication. This case highlights the possibility of dual tolerance in pediatric ABO-incompatible liver transplantation and provides insights into immune tolerance mechanisms, with implications for enhancing patient care and reducing healthcare costs. Further research is necessary to clarify these mechanisms and to evaluate the long-term durability of tolerance in pediatric transplant recipients.
Details
- Language :
- English
- ISSN :
- 26718790
- Volume :
- 37
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Korean Journal of Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9d560ce6415c45d88a83ec6259355e9c
- Document Type :
- article
- Full Text :
- https://doi.org/10.4285/kjt.23.0070