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Skeleton and Glucose Metabolism: A Bone-Pancreas Loop
- Source :
- International Journal of Endocrinology, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
- Subjects :
- Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Subjects
Details
- Language :
- English
- ISSN :
- 16878337 and 16878345
- Volume :
- 2015
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9c69821532df4b7f969b33acddb18d3d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2015/758148