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Potential value of pharmacological agents acting on toll-like receptor (TLR) 7 and/or TLR8 in COVID-19
- Source :
- Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100068- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The COVID-19 pandemic is an ongoing global pandemic of coronavirus disease 2019 as an atypical type of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many potential pharmacotherapies are currently being investigated against this disease. This article points to and justifies, the importance of investigating the potential therapeutic value of pharmacological agents acting on Toll-like Receptor (TLR) 7 and/or TLR8 as double-edged swords combating COVID-19. Induction of TLR7 and/or TLR8 may be investigated as a strategy to stimulate immunity and may be added to anti-COVID19 vaccines to cope with their current viral escape challenge. TLR7 stimulation may not only help viral clearance through Th1 antiviral responses but may also provide beneficial broncho- and vaso-dilatory, as well as, anti-inflammatory effects. Pharmacological compounds acting as TLR7 and/or TLR8 agonists may be of value if used by frontline healthcare workers with comorbidities who demonstrate mild symptoms of the disease. On the other hand, TLR7 and/or TLR8 antagonists may be used in combination with immune-modulatory/anti-inflammatory drugs in severe cases of the disease, with potential synergistic effects that could also help in reducing the doses of such therapies, and consequently their adverse effects.
- Subjects :
- Agonists
Antagonists
COVID-19
TLR7
TLR8
Vaccines
Therapeutics. Pharmacology
RM1-950
Subjects
Details
- Language :
- English
- ISSN :
- 25902571
- Volume :
- 2
- Issue :
- 100068-
- Database :
- Directory of Open Access Journals
- Journal :
- Current Research in Pharmacology and Drug Discovery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9c5eb814fe3485b97f0ef66eb4600a3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.crphar.2021.100068