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Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

Authors :
Teodora Eliana Petcov
Mihai Straticiuc
Decebal Iancu
Dragoș Alexandru Mirea
Roxana Trușcă
Paul Emil Mereuță
Diana Iulia Savu
George Dan Mogoșanu
Laurențiu Mogoantă
Roxana Cristina Popescu
Verena Kopatz
Sorin Ion Jinga
Source :
Journal of Functional Biomaterials, Vol 15, Iss 6, p 169 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well as higher comfort for the patient. The current advancements in cancer treatment based on nanotechnology exploit the ability of these systems to pass biological barriers to target the tumor cell, as well as tumor cell organelles. In particular, iron oxide NPs are being clinically employed in oncological management due to this ability. When designing an efficient anti-cancer therapy based on NPs, it is important to know and to modulate the phenomena which take place during the interaction of the NPs with the tumor cells, as well as the normal tissues. In this regard, our review is focused on highlighting different approaches to studying the internalization patterns of iron oxide NPs in simple and complex 2D and 3D in vitro cell models, as well as in living tissues, in order to investigate the functionality of an NP-based treatment.

Details

Language :
English
ISSN :
20794983
Volume :
15
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Journal of Functional Biomaterials
Publication Type :
Academic Journal
Accession number :
edsdoj.9c2aa4156c124f888a8556a7f136af2d
Document Type :
article
Full Text :
https://doi.org/10.3390/jfb15060169