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Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy
- Source :
- Majalah Kedokteran Bandung, Vol 54, Iss 1, Pp 57-62 (2022)
- Publication Year :
- 2022
- Publisher :
- Universitas Padjajaran, 2022.
-
Abstract
- Spinocerebellar ataxia (SCA) 3 is a neurodegenerative disease which involves cerebellum and extra cerebellum. Neuropathy in SCA3 manifests in various ways, including axonal and demyelination lesions in sensory and motor nerves. There has not been any study that describes the peripheral neuropathy characteristics of SCA3 patients in Indonesia at the time of this publication. This paper reports a case of a 43-year-old male with known spinocerebellar ataxia 3 presented with hereditary ataxia and mild numbness in both palms since two years before. No abnormalities were found during the sensory examination. The NCS showed severe axonal demyelinating sensorimotor peripheral neuropathy. In magnetic resonance imaging (MRI), an atrophy in the cerebellum with cerebral multiple lacunar infarction was identified. Electrophysiological results revealed profound axonal lesion in peripheral nerves. To conclude, peripheral neuropathy in SCA3 represents the dominance of axonal lesions in motor nerves.
- Subjects :
- ncs, peripheral neuropathy, sca3
Medicine
Subjects
Details
- Language :
- English, Indonesian
- ISSN :
- 0126074X and 23386223
- Volume :
- 54
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Majalah Kedokteran Bandung
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9c25b22f9df34d058c53978e1df454c4
- Document Type :
- article
- Full Text :
- https://doi.org/10.15395/mkb.v54n1.2394