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Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Authors :
Haisheng Yu
Banghui Liu
Yudi Zhang
Xijie Gao
Qian Wang
Haitao Xiang
Xiaofang Peng
Caixia Xie
Yaping Wang
Peiyu Hu
Jingrong Shi
Quan Shi
Pingqian Zheng
Chengqian Feng
Guofang Tang
Xiaopan Liu
Liliangzi Guo
Xiumei Lin
Jiaojiao Li
Chuanyu Liu
Yaling Huang
Naibo Yang
Qiuluan Chen
Zimu Li
Mengzhen Su
Qihong Yan
Rongjuan Pei
Xinwen Chen
Longqi Liu
Fengyu Hu
Dan Liang
Bixia Ke
Changwen Ke
Feng Li
Jun He
Meiniang Wang
Ling Chen
Xiaoli Xiong
Xiaoping Tang
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9b9eeb66b96c4be0aef6038b90a860fc
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36761-0