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A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- TNFSF14 (LIGHT) contributes to airway inflammation and remodelling. Here the authors show that TNFSF14 acting on its receptor TNFRSF14 on mast cells enhances their IgE-dependent activation and that interference with this pathway attenuates features of asthma pathology in mice.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9b661fd658a64195915d136587d50be7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms13696