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Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Authors :
Aliza P. Wingo
Eric B. Dammer
Michael S. Breen
Benjamin A. Logsdon
Duc M. Duong
Juan C. Troncosco
Madhav Thambisetty
Thomas G. Beach
Geidy E. Serrano
Eric M. Reiman
Richard J. Caselli
James J. Lah
Nicholas T. Seyfried
Allan I. Levey
Thomas S. Wingo
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with cognitive resilience.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9b58a9346e234b21a9e82096eeb3d508
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-09613-z