Progress in Research on Biomarkers of Gestational Diabetes Mellitus and Preeclampsia

Yang Liu,1 Dan Yang Li,1 Alayi Bolatai,2 Na Wu1,3 1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’ s Republic of China; 2Department of Student Affairs, Affiliated Hospital of China Medical University, Shenyang, Liaoning, People’ s Republic of China; 3Medical Department, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’ s Republic of ChinaCorrespondence: Na Wu, Email 3441535223@qq.comAbstract: Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common complications in pregnancy, with incidence rates of 1– 5% and 9.4%, respectively, in China. Both these phenomena can cause adverse pregnancy outcomes and are extremely harmful to the mother and fetus. In this study, we observed that several predictive factors have important value in GDM and PE. Among the GDM group, abnormal levels of adiponectin (APN), C-reactive protein (CRP), and Leptin were observed. The coexistence of PE and GDM in the pregnant population is not uncommon. Ultimately, we discovered abnormal levels of factors such as Visfatin, Advanced oxidative protein product (AOPP), Fibroblast growth factor 21 (FGF21), and resistin in both GDM and PE groups. Particularly, the FGF21 factor holds significant importance in our research. Therefore, we need to complete the analysis and discussion of relevant predictive factors to enable early prediction and disease monitoring of GDM, PE, and other pregnancy-related disorders, ultimately contributing to the long-term health of pregnant women.Keywords: gestational diabetes mellitus, preeclampsia, predictor of the GDM and PE