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Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals
- Source :
- Infectious Diseases and Therapy, Vol 9, Iss 4, Pp 837-849 (2020)
- Publication Year :
- 2020
- Publisher :
- Adis, Springer Healthcare, 2020.
-
Abstract
- Abstract Background Serology testing is explored for epidemiological research and to inform individuals after suspected infection. During the coronavirus disease 2019 (COVID-19) pandemic, frontline healthcare professionals (HCP) may be at particular risk for infection. No longitudinal data on functional seroconversion in HCP in regions with low COVID-19 prevalence and low pre-test probability exist. Methods In a large German university hospital, we performed weekly questionnaire assessments and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) measurements with various commercial tests, a novel surrogate virus neutralisation test, and a neutralisation assay using live SARS-CoV-2. Results From baseline to week 6, 1080 screening measurements for anti-SARS CoV-2 (S1) IgG from 217 frontline HCP (65% female) were performed. Overall, 75.6% of HCP reported at least one symptom of respiratory infection. Self-perceived infection probability declined over time (from mean 20.1% at baseline to 12.4% in week 6, p
Details
- Language :
- English
- ISSN :
- 21938229, 21936382, and 03999505
- Volume :
- 9
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Infectious Diseases and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9b00ce0e08fa4b03999505491b0dadf1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s40121-020-00334-1