The expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury

Abstract Purpose We sought to investigate the expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury. Methods The current retrospective analysis focused on 146 sepsis patients admitted to our hospital from February 2021 to March 2023. Based on the presence or absence of myocardial injury, the patients were divided into two groups: the sepsis group (n = 80) and the sepsis-induced myocardial injury group (n = 66). Based on the 28-day mortality status of the patients, they were also divided into a survival group of 143 cases and a death group of 3 cases. The study compared the levels of MALAT1, plasma brain natriuretic peptide, and Tei index between the sepsis group and sepsis-induced myocardial injury group, as well as the comparison of two sets of ultrasound indicators. Univariate logistic regression analysis was performed to identify the influencing factors of sepsis-induced myocardial injury, followed by multivariate logistic regression analysis to identify the influencing factors of such condition. MALAT1, plasma brain natriuretic peptide and cardiac Tei index between the survival and death groups were compared and Pearson correlation analysis was conduct to assess their correlations. Results In terms of general information, there were no significant differences in gender, age, BMI, mean arterial pressure, systolic pressure, diastolic pressure, respiratory rate, oxygenation index, basic diseases and infection site between the two groups (P > 0.05). However, significant differences were observed in heart rate, SOFA score, and APACHE II score between the two groups (P