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Association of Gestational Diabetes With Subclinical Cardiovascular Disease
- Source :
- JACC: Advances, Vol 3, Iss 8, Pp 101111- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Background: Gestational diabetes mellitus (GDM) is associated with increased long-term risk of cardiovascular disease but the cardiovascular structural and functional changes that contribute to risk are not well understood. Objectives: The purpose of this study was to determine whether GDM is associated with adverse cardiac remodeling and endothelial dysfunction a decade after delivery, independent of type 2 diabetes. Methods: Women with deliveries between 2008 and 2009 were initially selected from a prospective clinical cohort. Pregnancy history was chart abstracted and a follow-up study visit was conducted at 8 to 10 years postpartum. Cardiac structure and function were assessed with echocardiography. Endothelial function was measured with peripheral arterial tonometry and glycocalyx analysis. Results: Among 254 women assessed at an average age of 38 years, 53 (21%) had prior GDM. At follow-up, women with GDM had more incident prediabetes or diabetes (58% vs 20% without GDM), more impairment in peripheral arterial tonometry (reactive hyperemia 1.58 vs 1.95; P = 0.01) and reduced perfusion, a marker of glycocalyx assessment (red blood cell filling 0.70 ± 0.04 vs 0.72 ± 0.05; P
Details
- Language :
- English
- ISSN :
- 2772963X
- Volume :
- 3
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- JACC: Advances
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9ae4f52acbe74fd08e9f2d7a5325a7a9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jacadv.2024.101111