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Mitochondrial Plasticity and Glucose Metabolic Alterations in Human Cancer under Oxidative Stress—From Viewpoints of Chronic Inflammation and Neutrophil Extracellular Traps (NETs)

Authors :
Hui-Ting Lee
Chen-Sung Lin
Chao-Yu Liu
Po Chen
Chang-Youh Tsai
Yau-Huei Wei
Source :
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9458 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Oxidative stress elicited by reactive oxygen species (ROS) and chronic inflammation are involved both in deterring and the generation/progression of human cancers. Exogenous ROS can injure mitochondria and induce them to generate more endogenous mitochondrial ROS to further perpetuate the deteriorating condition in the affected cells. Dysfunction of these cancer mitochondria may possibly be offset by the Warburg effect, which is characterized by amplified glycolysis and metabolic reprogramming. ROS from neutrophil extracellular traps (NETs) are an essential element for neutrophils to defend against invading pathogens or to kill cancer cells. A chronic inflammation typically includes consecutive NET activation and tissue damage, as well as tissue repair, and together with NETs, ROS would participate in both the destruction and progression of cancers. This review discusses human mitochondrial plasticity and the glucose metabolic reprogramming of cancer cells confronting oxidative stress by the means of chronic inflammation and neutrophil extracellular traps (NETs).

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
17
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.9ac9525ba98486aa81ad9ef53335bfb
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25179458