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Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection

Authors :
Sanjeev Gurshaney
Anamaria Morales-Alvarez
Kevin Ezhakunnel
Andrew Manalo
Thien-Huong Huynh
Jun-Ichi Abe
Nhat-Tu Le
Daniela Weiskopf
Alessandro Sette
Daniel S. Lupu
Stephen J. Gardell
Hung Nguyen
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Mitophagy inhibition rescues cellular dysfunction through enhancing metabolic fitness in CD8 and NKT lymphocytes during SARS-CoV-2 infection.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.9aade89ad179404b824494c7ad2a81d4
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04730-4