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Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

Authors :
Kyle Rosenke
Frederick Hansen
Benjamin Schwarz
Friederike Feldmann
Elaine Haddock
Rebecca Rosenke
Kent Barbian
Kimberly Meade-White
Atsushi Okumura
Shanna Leventhal
David W. Hawman
Emily Ricotta
Catharine M. Bosio
Craig Martens
Greg Saturday
Heinz Feldmann
Michael A. Jarvis
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al. provide evidence that orally delivered MK-4482, a nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9a78a63a312847aa863ae1016f4d581a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-22580-8