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Bone Mineral Density among adolescent's patients with β-thalassemia major.

Authors :
Samar Abbas Jaffri
Syed Muhammad Irfan
Sadia Sultan
Syed Muhammad Usman
Sheeza Nadeem
Source :
International Journal of Endorsing Health Science Research, Vol 9, Iss 1, Pp 42-47 (2021)
Publication Year :
2021
Publisher :
Advance Educational Institute & Research Centre, 2021.

Abstract

Background:Beta-thalassemia is an autosomal recessivehemoglobinopathy with frequent skeletal complications, often debilitating in adolescent patients. We aim to evaluate the bone mineral density (BMD) by dual-energy x-ray absorptiometry (DEXA) and ascertain osteoporosis/osteopenia frequency in patients with β-thalassemia major. Methodology:In this cross-sectional study, 36 adolescent patients with β-thalassemia major were enrolled from June 2015 to March 2017. BMD was measured in the anteroposterior lumbar spine (L1-L4) and femoral neck by DEXA. For the biochemical estimations, blood and urine samples were obtained and analyzed. The results of a bone density test were presented as T and Z scores. Results:There were 20 male and 16 female patients with a mean age of 21.33 ± 3.7 years. The mean bone mineral content (BMC) was 20.10 ± 6.0 gm, and the mean BMD was0.65 ± 0.07 gm/cm2. The mean T score was -3.17 ± 1.04, and the Z score was -3.06 ± 1.06. All patients had low BMD, as depicted by their T or Z scores. The reported frequency of osteoporosis and osteopenia was 77.7% and 22.2%, respectively. Conclusion:All Beta-thalassemia major patients had low BMD with a remarkable incidence of osteoporosis. It is recommended to perform an annual BMD among thalassemic patients to prevent fatal consequences and achieve an optimal bone density among such patients.

Details

Language :
English
ISSN :
23073748 and 23103841
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
International Journal of Endorsing Health Science Research
Publication Type :
Academic Journal
Accession number :
edsdoj.9a55862198d445f29acf99ccc26d9b46
Document Type :
article
Full Text :
https://doi.org/10.29052/IJEHSR.v9.i1.2021.42-47