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In vitro cytocompatibility of triclosan coated Polyglactin910 sutures
- Source :
- Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-6 (2024)
- Publication Year :
- 2024
- Publisher :
- Springer, 2024.
-
Abstract
- Abstract Bioabsorbable sutures can improve the medical functions of existing non-absorbable sutures, and may produce new medical effects, and are expected to become a new generation of medical degradable materials. In this study, the cytocompatibility of triclosan coated polyglactin910 sutures (CTS-PLGA910) was analyzed and different concentrations of sutures were prepared. The effects of sutures on the cytotoxicity and cell proliferation of HUVEC were studied by CCK-8 assay. The hemolysis, total antioxidant capacity (T-AOC) activity and nitric oxide (NO) content were investigated to improve the blood compatibility of sutures. The results showed that the hemolysis rate of CTS-PLGA910 was less than 5%. After treatment on HUVEC cells for 48 and 72 h, there was no significant change in NO content in CTS-PLGA910 groups compared with the control group, while T-AOC activity and antioxidant capacity were significantly increased in medium and high dose groups. In summary, the blood compatibility and cell compatibility were significantly improved, which provided a basis for the clinical application of sutures in the future. Graphical Abstract
Details
- Language :
- English
- ISSN :
- 15734838
- Volume :
- 35
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Materials Science: Materials in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9a49575a8bf0447ca8064f3598555fe6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s10856-024-06796-w