Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Authors :: Erik J. Hasenoehrl
Dannah Rae Sajorda
Linda Berney-Meyer
Samantha Johnson
JoAnn M. Tufariello
Tobias Fuhrer
Gregory M. Cook
William R. Jacobs
Michael Berney
Source :: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Publication Year :: 2019
Publisher :: Nature Portfolio, 2019.
Abstract: Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets for drug development.

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