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Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Authors :
Mingjing Hu
David Eviston
Peter Hsu
Eliana Mariño
Ann Chidgey
Brigitte Santner-Nanan
Kahlia Wong
James L. Richards
Yu Anne Yap
Fiona Collier
Ann Quinton
Steven Joung
Michael Peek
Ron Benzie
Laurence Macia
David Wilson
Ann-Louise Ponsonby
Mimi L. K. Tang
Martin O’Hely
Norelle L. Daly
Charles R. Mackay
Jane E. Dahlstrom
The BIS Investigator Group
Peter Vuillermin
Ralph Nanan
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9a435d8124048e595fe54577e177533
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-10703-1