Back to Search
Start Over
Metastatic Urothelial Tumor Progression Following First Line Chemotherapy: Prognostic Factors and Importance of Second Line Chemotherapy
- Source :
- Middle East Journal of Cancer, Vol 9, Iss 3, Pp 195-201 (2018)
- Publication Year :
- 2018
- Publisher :
- Shiraz University of Medical Sciences, 2018.
-
Abstract
- Background: Limited data exists to support the benefit from second-line chemotherapy in patients with metastatic urothelial carcinoma. Factors that predict survival following progression after first-line platinum-based regimens in patients treated outside clinical trials are not clear. This study intends to evaluate different prognostic factors and the impact of second-line chemotherapy on survival. Methods: We retrospectively reviewed patients with metastatic urothelial carcinoma who experienced disease progression following first-line platinum-based regimens for metastases. These patients received treatment and follow up visits at a single institution. The effect of demographic, disease characteristics, and second-line therapy on overall survival was examined through univariate and multivariate cox-regression analyses. Results: There were 64 patients included. A total of 27 (42%) patients did not receive second-line chemotherapy because of poor Eastern Cooperative Oncology Group performance status, 20 (31%) received combination chemotherapy (platinum-based in 17), and 17 (27%) received a single agent chemotherapy. The median overall survival from the date of documented progression after first-line therapy was 5.0 months. In multivariate analysis, a correlation existed between poor overall survival and performance status of ≥1 (HR: 5.74, 95% CI: 1.4- 45.57, P=0.036), no second-line chemotherapy (HR: 2.72, 95% CI: 1.39-5.31, P=0.003), and ≥2 metastatic sites (HR: 5.19, 95% CI: 1.74-15.44, P
Details
- Language :
- English
- ISSN :
- 20086709 and 20086687
- Volume :
- 9
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Middle East Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.98f9e65d72ef4bb283f0d39cf8218056
- Document Type :
- article