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Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

Authors :
Calwing Liao
Alexandre D. Laporte
Dan Spiegelman
Fulya Akçimen
Ridha Joober
Patrick A. Dion
Guy A. Rouleau
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

A recent GWAS reported 12 genetic loci for attention deficit/hyperactivity disorder (ADHD). Here, Liao et al. perform transcriptomic imputation using these data and 12 brain-relevant tissues from GTEx and CMC to identify 9 genes associated with ADHD by TWAS, 3 of which had not yet been reported for ADHD.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.98989c48e5614c72b3a29f0f4c4ddced
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12450-9