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The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

Authors :
Burak H. Alver
Kimberly H. Kim
Ping Lu
Xiaofeng Wang
Haley E. Manchester
Weishan Wang
Jeffrey R. Haswell
Peter J. Park
Charles W. M. Roberts
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

SWI/SNF chromatin remodelling complex is a major regulator of chromatin structure and of transcription. Here, using mouse embryonic fibroblasts and human rhabdoid tumour cells, the authors provide evidence that SWI/SNF functions as a regulator of enhancers.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.987848cfa7004d11b8b1c3154bd8c459
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms14648