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Differential Long-Term Effects of First- and Second-Generation DES in Patients With Bifurcation Lesions Undergoing PCI

Authors :
Ki Hong Choi, MD
Young Bin Song, MD
Joo Myung Lee, MD
Taek Kyu Park, MD
Jeong Hoon Yang, MD
Joo-Yong Hahn, MD
Jin-Ho Choi, MD
Seung-Hyuk Choi, MD
Hyo-Soo Kim, MD
Woo Jung Chun, MD
Seung-Ho Hur, MD
Seung Hwan Han, MD
Seung-Woon Rha, MD
In-Ho Chae, MD
Jin-Ok Jeong, MD
Jung Ho Heo, MD
Junghan Yoon, MD
Do-Sun Lim, MD
Jong-Seon Park, MD
Myeong-Ki Hong, MD
Joon-Hyung Doh, MD
Kwang Soo Cha, MD
Doo-Il Kim, MD
Sang Yeub Lee, MD
Kiyuk Chang, MD
Byung-Hee Hwang, MD
So-Yeon Choi, MD
Myung Ho Jeong, MD
Soon-Jun Hong, MD
Chang-Wook Nam, MD
Bon-Kwon Koo, MD
Hyeon-Cheol Gwon, MD
Source :
JACC: Asia, Vol 1, Iss 1, Pp 68-79 (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Background: There is a paucity of data regarding the long-term clinical outcomes of first- versus second-generation drug-eluting stent (DES), especially when used to treat complex lesions such as bifurcation lesions. Objectives: The current study compares the efficacy and safety of first- versus second-generation DES at the 5-year follow-up in patients who underwent bifurcation percutaneous coronary intervention (PCI). Methods: A total of 5,498 patients with a bifurcation lesion who underwent PCI were pooled at a single patient level from COBIS (Coronary Bifurcation Stenting) registries II and III. Five-year target lesion failure (TLF) (the composite of cardiac death, myocardial infarction [MI], and target lesion revascularization [TLR]) and cardiac death or MI were compared between the use of first-generation DES (n = 2,436) and second-generation DES (n = 3,062) during PCI. Propensity score matching was performed to reduce selection bias. Results: After a 1:1 propensity score matching procedure was conducted, the cohort consisted of 1,702 matched pairs. Patients treated with second-generation DES had a significantly lower risk of TLF at 5 years than those treated with first-generation DES in both overall and propensity-matched populations (matched hazard ratio [HRmatched]: 0.576; 95% confidence interval [CI]: 0.456 to 0.727; p

Details

Language :
English
ISSN :
27723747
Volume :
1
Issue :
1
Database :
Directory of Open Access Journals
Journal :
JACC: Asia
Publication Type :
Academic Journal
Accession number :
edsdoj.98631abe99146e5a9fed3f8d27d28cd
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jacasi.2021.04.006