Back to Search
Start Over
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.985e83249405455e850f73d41a842e97
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-12529-3