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Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021–June 2023

Authors :
Olivia Almendares
Julia M. Baker
David E. Sugerman
Umesh D. Parashar
Sarah Reagan-Steiner
Hannah L. Kirking
Paul A. Gastañaduy
Jacqueline E. Tate
Source :
Emerging Infectious Diseases, Vol 30, Iss 4, Pp 644-653 (2024)
Publication Year :
2024
Publisher :
Centers for Disease Control and Prevention, 2024.

Abstract

During October 2021–June 2023, a total of 392 cases of acute hepatitis of unknown etiology in children in the United States were reported to Centers for Disease Control and Prevention as part of national surveillance. We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance of continued investigation to determine the mechanism of liver injury and appropriate treatment. Testing for adenovirus in similar cases could elucidate the role of the virus.

Details

Language :
English
ISSN :
10806040 and 10806059
Volume :
30
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.984bd691fd664f9c8df5d71022ed95e3
Document Type :
article
Full Text :
https://doi.org/10.3201/eid3004.231140