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Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Authors :
Rupert L. Mayer
Rein Verbeke
Caroline Asselman
Ilke Aernout
Adillah Gul
Denzel Eggermont
Katie Boucher
Fabien Thery
Teresa M. Maia
Hans Demol
Ralf Gabriels
Lennart Martens
Christophe Bécavin
Stefaan C. De Smedt
Bart Vandekerckhove
Ine Lentacker
Francis Impens
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.97f012cb13b5447e97faef124f7e4dca
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33721-y