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Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets
- Source :
- Acta Pharmaceutica, Vol 67, Iss 2, Pp 237-246 (2017)
- Publication Year :
- 2017
- Publisher :
- Sciendo, 2017.
-
Abstract
- Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash®) required for the compression of Ibuprofen DC 85TM in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation.
- Subjects :
- ibuprofen dc 85tm
ludiflash®
orodispersible
sedem
Pharmaceutical industry
HD9665-9675
Subjects
Details
- Language :
- English
- ISSN :
- 18469558 and 20170017
- Volume :
- 67
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Pharmaceutica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.97ed937bb94b0bb522ef5a1f9fab9f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/acph-2017-0017