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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors :
Yan Zhan
Yufang Zhu
Shanshan Wang
Shijun Jia
Yunling Gao
Yingying Lu
Caili Zhou
Ran Liang
Dingwen Sun
Xiaobo Wang
Zhibing Hou
Qiaoqiao Hu
Peng Du
Hao Yu
Chang Liu
Miao Cui
Gangling Tong
Zhihua Zheng
Yunsheng Xu
Linyu Zhu
Jin Cheng
Feng Wu
Yulan Zheng
Peijun Liu
Peng Hong
Source :
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Publishing Group, 2021.

Abstract

Abstract The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life. Here we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang, China at 1-year after diagnosis. Among them, chemiluminescence immunoassay-based screening showed 99% (95% CI, 98–100%) seroprevalence 10–12 months after infection, comparing to 0.8% (95% CI, 0.7–0.9%) in the general population. Total anti-receptor-binding domain (RBD) antibodies remained stable since discharge, while anti-RBD IgG and neutralization levels decreased over time. A predictive model estimates 17% (95% CI, 11–24%) and 87% (95% CI, 80–92%) participants were still 50% protected against detectable and severe re-infection of WT SARS-CoV-2, respectively, while neutralization levels against B.1.1.7 and B.1.351 variants were significantly reduced. All non-severe patients showed normal chest CT and 21% reported COVID-19-related symptoms. In contrast, 53% severe patients had abnormal chest CT, decreased pulmonary function or cardiac involvement and 79% were still symptomatic. Our findings suggest long-lasting immune protection after SARS-CoV-2 infection, while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors.

Details

Language :
English
ISSN :
20593635
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Signal Transduction and Targeted Therapy
Publication Type :
Academic Journal
Accession number :
edsdoj.97ec9a5c281643399fdd8cd9cfc3c33a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41392-021-00777-z