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The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan

Authors :
Wenfeng Li
Shuming Chen
Jing Lang
Jing Luo
Jiahui Chen
Liping Zhang
Zhijie Sun
Deli Dong
Source :
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3266-3280 (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

The drugs extending healthspan in clinic have always been searched. Nitazoxanide is an FDA-approved clinical antiprotozoal drug. Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo. Our previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK, oral nitazoxanide protects against experimental hyperlipidemia, hepatic steatosis, and atherosclerosis. Here, we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 pathway. Additionally, both nitazoxanide and tizoxanide improve high glucose-induced shortening of C. elegans lifespan. Nitazoxanide has been a clinical drug with a good safety profile, we suggest that it is a novel anti-aging drug.

Details

Language :
English
ISSN :
22113835
Volume :
14
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Acta Pharmaceutica Sinica B
Publication Type :
Academic Journal
Accession number :
edsdoj.97e426a84d445f1b4e36333464de582
Document Type :
article
Full Text :
https://doi.org/10.1016/j.apsb.2024.03.031