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Cortical arousal in children and adolescents with functional neurological symptoms during the auditory oddball task

Authors :
Kasia Kozlowska, MBBS., PhD. FRANZCP
Dmitriy Melkonian, PhD. DSc
Chris J. Spooner, Bachelors of Engineering
Stephen Scher, PhD, JD
Russell Meares, MD, FRANZCP, FRCPsych
Source :
NeuroImage: Clinical, Vol 13, Iss C, Pp 228-236 (2017)
Publication Year :
2017
Publisher :
Elsevier, 2017.

Abstract

Objective: Stress, pain, injury, and psychological trauma all induce arousal-mediated changes in brain network organization. The associated, high level of arousal may disrupt motor-sensory processing and result in aberrant patterns of motor function, including functional neurological symptoms. We used the auditory oddball paradigm to assess cortical arousal in children and adolescents with functional neurological symptom disorder. Method: Electroencephalogram (EEG) data was collected in fifty-seven children and adolescents (41 girls; 16 boys, aged 8.5–18 years) with acute functional neurological symptoms and age- sex- matched controls during a conventional auditory oddball task. The high-resolution fragmentary decomposition technique was used to analyse the amplitude of event-related potentials (ERPs) to target tones at midline sites (Fz, Cz, and Pz). Results: Compared to age- and sex-matched controls, and across all three midline sites, children and adolescents with functional neurological symptoms showed increased amplitude of all ERP components (P50, N100, P200, N200, and P300) (t-value range 2.28–8.20; p value-range 0.023 to

Details

Language :
English
ISSN :
22131582
Volume :
13
Issue :
C
Database :
Directory of Open Access Journals
Journal :
NeuroImage: Clinical
Publication Type :
Academic Journal
Accession number :
edsdoj.97e34b6384da4e329c6c393ec9c6e279
Document Type :
article
Full Text :
https://doi.org/10.1016/j.nicl.2016.10.016