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Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

Authors :
Emily Dosmar
Gabrielle Vuotto
Xingqi Su
Emily Roberts
Abigail Lannoy
Garet J. Bailey
William F. Mieler
Jennifer J. Kang-Mieler
Source :
Pharmaceutics, Vol 13, Iss 11, p 1862 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartmental and four COMSOL models of the eye were developed to describe transport into the vitreous originating from a DDS placed topically, in the subconjunctiva, subretinally, and intravitreally. The concentration of the simulated DDS was assumed to be the initial concentration of the hydrogel DDS. The simulation was executed over 1500 and 100 h for the compartmental and COMSOL models, respectively. Based on the MATLAB model, topical, subconjunctival, subretinal and vitreous administration took most (~500 h to least (0 h) amount of time to reach peak concentrations in the vitreous, respectively. All routes successfully achieved therapeutic levels of drug (0.007 mg/mL) in the vitreous. These models predict the relative build-up of drug in the vitreous following DDS administration in four different points of origin in the eye. Our model may eventually be used to explore the minimum loading dose of drug required in our DDS leading to reduced drug use and waste.

Details

Language :
English
ISSN :
19994923
Volume :
13
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.97dccf7d2ef4faf9cfcbbb4ff1e9c77
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics13111862