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Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity

Authors :
Derrick P. McVicker
Adam M. Awe
Karl E. Richters
Rebecca L. Wilson
Diana A. Cowdrey
Xindao Hu
Edwin R. Chapman
Erik W. Dent
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Transport of cargo into dendritic spines is required for synaptic plasticity. McVicker et al.describe a method of activity-dependent transport of a kinesin KIF1A and its cargo synaptotagmin-IV along microtubules that are transiently polymerized into dendritic spines.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.97d348539938458194a7b5686b6dbfb8
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms12741