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Multiplication rate variation of malaria parasites from hospital cases and community infections
- Source :
- Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)
- Publication Year :
- 2025
- Publisher :
- Nature Portfolio, 2025.
-
Abstract
- Abstract The significance of multiplication rate variation in malaria parasites needs to be determined, particularly for Plasmodium falciparum, the species that causes most virulent infections. To investigate this, parasites from cases presenting to hospital in The Gambia and from local community infections were culture-established and then tested under exponential growth conditions in a standardised six-day multiplication rate assay. The multiplication rate distribution was lower than seen previously in clinical isolates from another area in West Africa where infection is more highly endemic. Multiplication rates were higher in cultured isolates derived from hospital cases (N = 23, mean = 2.9-fold per 48 h) than in those from community infections (N = 11, mean = 1.8-fold)(Mann-Whitney P
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 15
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.97d0e4700a08425fbb53245e8a57497a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41598-024-82916-4