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Multiplication rate variation of malaria parasites from hospital cases and community infections

Authors :
Lindsay B. Stewart
Elena Lantero Escolar
James Philpott
Antoine Claessens
Alfred Amambua-Ngwa
David J. Conway
Source :
Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)
Publication Year :
2025
Publisher :
Nature Portfolio, 2025.

Abstract

Abstract The significance of multiplication rate variation in malaria parasites needs to be determined, particularly for Plasmodium falciparum, the species that causes most virulent infections. To investigate this, parasites from cases presenting to hospital in The Gambia and from local community infections were culture-established and then tested under exponential growth conditions in a standardised six-day multiplication rate assay. The multiplication rate distribution was lower than seen previously in clinical isolates from another area in West Africa where infection is more highly endemic. Multiplication rates were higher in cultured isolates derived from hospital cases (N = 23, mean = 2.9-fold per 48 h) than in those from community infections (N = 11, mean = 1.8-fold)(Mann-Whitney P

Details

Language :
English
ISSN :
20452322
Volume :
15
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.97d0e4700a08425fbb53245e8a57497a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-024-82916-4