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Clostridium perfringens in the Intestine: Innocent Bystander or Serious Threat?

Authors :
Xuli Ba
Youshun Jin
Xuan Ning
Yidan Gao
Wei Li
Yunhui Li
Yihan Wang
Jizhang Zhou
Source :
Microorganisms, Vol 12, Iss 8, p 1610 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The Clostridium perfringens epidemic threatens biosecurity and causes significant economic losses. C. perfringens infections are linked to more than one hundred million cases of food poisoning annually, and 8–60% of susceptible animals are vulnerable to infection, resulting in an economic loss of more than 6 hundred million USD. The enzymes and toxins (>20 species) produced by C. perfringens play a role in intestinal colonization, immunological evasion, intestinal micro-ecosystem imbalance, and intestinal mucosal disruption, all influencing host health. In recent decades, there has been an increase in drug resistance in C. perfringens due to antibiotic misuse and bacterial evolution. At the same time, traditional control interventions have proven ineffective, highlighting the urgent need to develop and implement new strategies and approaches to improve intervention targeting. Therefore, an in-depth understanding of the spatial and temporal evolutionary characteristics, transmission routes, colonization dynamics, and pathogenic mechanisms of C. perfringens will aid in the development of optimal therapeutic strategies and vaccines for C. perfringens management. Here, we review the global epidemiology of C. perfringens, as well as the molecular features and roles of various virulence factors in C. perfringens pathogenicity. In addition, we emphasize measures to prevent and control this zoonotic disease to reduce the transmission and infection of C. perfringens.

Details

Language :
English
ISSN :
20762607
Volume :
12
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.97c1295059234f34bda07acfe50b06bc
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms12081610