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A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- 2D-thermal proteome profiling (2D-TPP) is a powerful assay for probing interactions of proteins with small molecules in their native context. Here the authors provide a statistical method for false discovery rate controlled analysis for 2D-TPP applications.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.974e291ef1154bb3b9d13d00e51b2a9c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19529-8