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Enrofloxacin Pharmaceutical Formulations through the Polymer-Free Electrospinning of β-Cyclodextrin–oligolactide Derivatives

Authors :
Diana-Andreea Blaj
Cătălina Anișoara Peptu
Maricel Danu
Valeria Harabagiu
Cristian Peptu
Alexandra Bujor
Lăcrămioara Ochiuz
Cristina Gabriela Tuchiluș
Source :
Pharmaceutics, Vol 16, Iss 7, p 903 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Enrofloxacin (ENR), a member of the fluoroquinolone class of antibiotics, is widely used in veterinary medicine to treat bacterial infections. Like many antibiotics, ENR has limited water solubility and low bioavailability. To address these challenges, drug formulations using solid dispersions, nanosuspensions, surfactants, cocrystal/salt formation, and inclusion complexes with cyclodextrins may be employed. The approach described herein proposes the development of ENR formulations by co-electrospinning ENR with custom-prepared cyclodextrin–oligolactide (CDLA) derivatives. This method benefits from the high solubility of these derivatives, enabling polymer-free electrospinning. The electrospinning parameters were optimized to incorporate significant amounts of ENR into the CDLA nanofibrous webs, reaching up to 15.6% by weight. The obtained formulations were characterized by FTIR and NMR spectroscopy methods and evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. This study indicates that the presence of CDLA derivative does not inhibit the antibacterial activity of ENR, recommending these formulations for further development.

Details

Language :
English
ISSN :
19994923
Volume :
16
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.973085d42547e7a94c0e734c00796a
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics16070903