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Zwitterionic polymers-armored amyloid-like protein surface combats thrombosis and biofouling
- Source :
- Bioactive Materials, Vol 32, Iss , Pp 37-51 (2024)
- Publication Year :
- 2024
- Publisher :
- KeAi Communications Co., Ltd., 2024.
-
Abstract
- Proteins, cells and bacteria adhering to the surface of medical devices can lead to thrombosis and infection, resulting in significant clinical mortality. Here, we report a zwitterionic polymers-armored amyloid-like protein surface engineering strategy we called as “armored-tank” strategy for dual functionalization of medical devices. The “armored-tank” strategy is realized by decoration of partially conformational transformed LZM (PCTL) assembly through oxidant-mediated process, followed by armoring with super-hydrophilic poly-2-methacryloyloxyethyl phosphorylcholine (pMPC). The outer armor of the “armored-tank” shows potent and durable zone defense against fibrinogen, platelet and bacteria adhesion, leading to long-term antithrombogenic properties over 14 days in vivo without anticoagulation. Additionally, the “fired” PCTL from “armored-tank” actively and effectively kills both Gram-positive and Gram-negative bacterial over 30 days as a supplement to the lacking bactericidal functions of passive outer armor. Overall, this “armored-tank” surface engineering strategy serves as a promising solution for preventing biofouling and thrombotic occlusion of medical devices.
Details
- Language :
- English
- ISSN :
- 2452199X
- Volume :
- 32
- Issue :
- 37-51
- Database :
- Directory of Open Access Journals
- Journal :
- Bioactive Materials
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.966189f9eb9a42dd86a0bb0b5c5f749b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bioactmat.2023.09.003