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Association between interleukin-6 gene polymorphism and iron regulation in hemodialysis patients infected with HCV

Authors :
Yasser B.M. Ali
Saad G. Moussa
Samar M. Shahen
Mohammed A. Dewir
Ibrahim H. El-Sayed
Source :
Brazilian Journal of Nephrology, Vol 42, Iss 4, Pp 437-447 (2020)
Publication Year :
2020
Publisher :
Sociedade Brasileira de Nefrologia, 2020.

Abstract

ABSTRACT Backgrounds: Hepcidin is related to the pathogenesis of chronic renal failure anemia, which is considered a chronic inflammatory state as well as HCV infection. IL-6 stimulates the release of hepcidin from the liver, suppresses intestinal iron uptake, and releases iron from internal stores. Method: To detect the association between IL-6 gene polymorphism and anemia markers, 80 hemodialysis (HD) patients [40 negative HCV HD patients and 40 positive HCV HD patients] were studied by routine chemistry and complete blood count, in addition to the assessment of serum hepcidin, iron parameters [serum iron and serum ferritin], and hepatitis C markers. IL-6 polymorphism -174G/C was determined by MS-PCR, while IL-6 polymorphisms -597G/A and -572 G/C were detected by PCR-SSP. Results: Hepcidin was non-significantly elevated in HCV-positive compared with HCV-negative hemodialysis patients. A statistically significant difference was detected between the negative and positive HCV HD patients in frequencies of IL-6 -174 G/C and -597 G/A (P≤ 0.01 and P≤ 0.001, respectively). On the other hand, a non-significant difference was reported between negative and positive HCV HD patients in the frequencies of IL-6 -572 G/C. Conclusions: Our study indicated that IL-6 -174 G/C and -597 G/A polymorphisms may play a role in HCV susceptibility in HD patients. Additional prospective studies on a larger population are needed to confirm our findings.

Details

Language :
English, Portuguese
ISSN :
21758239
Volume :
42
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Brazilian Journal of Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.963f44788a1542549c27391e7565a907
Document Type :
article
Full Text :
https://doi.org/10.1590/2175-8239-jbn-2019-0188