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Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk

Authors :
Xuehai Wang
Michael Nissen
Deanne Gracias
Manabu Kusakabe
Guillermo Simkin
Aixiang Jiang
Gerben Duns
Clementine Sarkozy
Laura Hilton
Elizabeth A. Chavez
Gabriela C. Segat
Rachel Wong
Jubin Kim
Tomohiro Aoki
Rashedul Islam
Christina May
Stacy Hung
Kate Tyshchenko
Ryan R. Brinkman
Martin Hirst
Aly Karsan
Ciara Freeman
Laurie H. Sehn
Ryan D. Morin
Andrew J. Roth
Kerry J. Savage
Jeffrey W. Craig
Sohrab P. Shah
Christian Steidl
David W. Scott
Andrew P. Weng
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Follicular lymphoma can transform to a more aggressive histology. Here, the authors use bulk and single cell analysis to create a 26 marker panel which could be used to profile FL samples and predict the risk of transformation using flow cytometry.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.960f4dd0b9a426988ebdc70978507ff
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-34408-0