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STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.95f73b88a6d342eb9cd45626c936f80a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-06134-z