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Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting

Authors :
David Garrido
Virginia Bove
Fiorella Villano
Eloísa Riva
Source :
Acta Medica, Vol 66, Iss 3, Pp 117-121 (2024)
Publication Year :
2024
Publisher :
Karolinum Press, 2024.

Abstract

Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) outcomes after frontline ASCT in newly-diagnosed MM (NDMM) patients in a real-world setting. Methods: We conducted a retrospective, survival analysis of all NDMM patients included in the MM Uruguayan Registry. Results: We included 151 NDMM patients treated with induction therapy followed by high-dose melphalan and ASCT as consolidation. The median age at diagnosis was 59 years, and the international staging system (ISS) risk groups were ISS-III 32.9%, ISS-II 37.8%, and ISS-I 29.4%. Frontline induction regimens included bortezomib in 61.6% of cases, and maintenance therapy was used in 63.9% of reported cases. With a median follow-up of 42 months, the 36-month OS and PFS for the whole group were 82.4% (95% CI 75.9% to 89.4%) and 63.8% (95% CI 55.6% to 73.3%), respectively, median OS of 98 months and median PFS of 47 months. The 100-month OS and PFS for the entire group were 48.0% (95% CI 34.9% to 66.0%) and 17.3% (95% CI 8.4% to 35.8%), respectively. Conclusion: ASCT is a feasible, safe, and potent strategy that provides a prolonged median OS and PFS in NDMM patients. This approach can be implemented in low-income countries.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
18059694 and 12114286
Volume :
66
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Acta Medica
Publication Type :
Academic Journal
Accession number :
edsdoj.95d4f71ce56c459e8a13121a6838d291
Document Type :
article
Full Text :
https://doi.org/10.14712/18059694.2024.4