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Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes

Authors :
Andrii Slonchak
Leon E. Hugo
Morgan E. Freney
Sonja Hall-Mendelin
Alberto A. Amarilla
Francisco J. Torres
Yin Xiang Setoh
Nias Y. G. Peng
Julian D. J. Sng
Roy A. Hall
Andrew F. van den Hurk
Gregor J. Devine
Alexander A. Khromykh
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The function on subgenomic flaviviral RNA (sfRNA) in the mosquito vector is not well understood. Here, Slonchak et al. show that sfRNA affects virus-induced apoptosis and dissemination of ZIKV in Aedes aegypti mosquitoes, suggesting a role of sfRNA in Zika virus replication and transmission.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.95cc3ef3f6434f148f53dccae4ece433
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16086-y