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MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

Authors :
Iris Müller
Ann Sophie Moroni
Daria Shlyueva
Sudeep Sahadevan
Erwin M. Schoof
Aliaksandra Radzisheuskaya
Jonas W. Højfeldt
Tülin Tatar
Richard P. Koche
Chang Huang
Kristian Helin
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of LINE1 elements by MPP8 does not require chromatin binding, nor H3K9me3.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9597bd4ec7404890a76dbc8df6a59f5c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23308-4