Application of a xenopericardial plate for closing a laparostomy in conditions of a purulent-inflammatory process

The aim of the study is to study the morphological changes in tissue in the laparostomy area when it is closed with a xenopericardial plate under conditions of an active purulent-inflammatory process. Material and methods. Analysis of data from patients at the Penza regional clinical hospital named after. N.N. Burdenko, with diseases of the abdominal organs, complicated by diffuse purulent peritonitis. During treatment, xenopericardial plates with perforations in a checkerboard pattern were used (hole diameter 0.5 cm). Disinfection of the material was carried out with a sterile solution of furacilin. Using the standard hematoxylin and eosin staining protocol, as well as alternative staining methods according to Van Gieson and Weigert, light-optical examination of stained sections was carried out at a magnification of 40–400 times. Results. In 8 out of 9 patients participating in the study, a favorable course of the inflammatory process was observed; on the 21st day after laparotomy, the symptoms of peritonitis were eliminated, the surgical wound was sutured. In one case, progression of local and general signs of peritonitis was observed within two weeks. After replacing the xenopericardial plate, the course of changes in the surgical wound was favorable. On day 21, the laparotomy wound was also sutured. Repeated examination of the biomaterial one year and two months after implantation of the xenopericardial plate into the anterior abdominal wall did not reveal signs of inflammation. Conclusions. The xenopericardium performed well in conditions of purulent inflammation and in most cases was not subject to melting. In the long term, biointegration of the xenopericardium into its own connective tissue occurred.