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Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Facioscapulohumeral muscular dystrophy is a severe myopathy that is caused by abnormal activation of DUX4, and for which a suitable mouse model does not exist. Here, the authors generate a novel mouse model with titratable expression of DUX4, and show that it recapitulates several features of the human pathology.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9516fa4c1ad1467299b0aa2dfdddf207
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-00730-1