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NeuroRoots, a bio-inspired, seamless brain machine interface for long-term recording in delicate brain regions

Authors :
Marc D. Ferro
Christopher M. Proctor
Alexander Gonzalez
Sriram Jayabal
Eric Zhao
Maxwell Gagnon
Andrea Slézia
Jolien Pas
Gerwin Dijk
Mary J. Donahue
Adam Williamson
Jennifer Raymond
George G. Malliaras
Lisa Giocomo
Nicholas A. Melosh
Source :
AIP Advances, Vol 14, Iss 8, Pp 085109-085109-12 (2024)
Publication Year :
2024
Publisher :
AIP Publishing LLC, 2024.

Abstract

Scalable electronic brain implants with long-term stability and low biological perturbation are crucial technologies for high-quality brain–machine interfaces that can seamlessly access delicate and hard-to-reach regions of the brain. Here, we created “NeuroRoots,” a biomimetic multi-channel implant with similar dimensions (7 μm wide and 1.5 μm thick), mechanical compliance, and spatial distribution as axons in the brain. Unlike planar shank implants, these devices consist of a number of individual electrode “roots,” each tendril independent from the other. A simple microscale delivery approach based on commercially available apparatus minimally perturbs existing neural architectures during surgery. NeuroRoots enables high density single unit recording from the cerebellum in vitro and in vivo. NeuroRoots also reliably recorded action potentials in various brain regions for at least 7 weeks during behavioral experiments in freely-moving rats, without adjustment of electrode position. This minimally invasive axon-like implant design is an important step toward improving the integration and stability of brain–machine interfacing.

Subjects

Subjects :
Physics
QC1-999

Details

Language :
English
ISSN :
21583226
Volume :
14
Issue :
8
Database :
Directory of Open Access Journals
Journal :
AIP Advances
Publication Type :
Academic Journal
Accession number :
edsdoj.94e3d3238e3a4977996ef8f8acf6f986
Document Type :
article
Full Text :
https://doi.org/10.1063/5.0216979