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Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Authors :
Patrizia Garbati
Cristiana Picco
Raffaella Magrassi
Paolo Signorello
Ludovica Cacopardo
Mauro Dalla Serra
Maria Grazia Faticato
Maria De Luca
Francesco Balestra
Maria Principia Scavo
Federica Viti
Source :
Pharmaceutics, Vol 16, Iss 3, p 431 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical–chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.

Details

Language :
English
ISSN :
19994923
Volume :
16
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.945f1dfc9584455f85e31c3bdda786d9
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics16030431