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Serum alpha-fetoprotein response as a preoperative prognostic indicator in unresectable hepatocellular carcinoma with salvage hepatectomy following conversion therapy: a multicenter retrospective study

Authors :
Kong-Ying Lin
Jian-Xi Zhang
Zhi-Wen Lin
Qing-Jing Chen
Liu-Ping Luo
Jin-Hong Chen
Kui Wang
Sheng Tai
Zhi-Bo Zhang
Shi-Feng Wang
Jing-Dong Li
Kai Wang
Lu Zheng
Si-Ming Zheng
Meng-Meng Wu
Ke-Can Lin
Tian Yang
Yong-Yi Zeng
Source :
Frontiers in Immunology, Vol 15 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

BackgroundThis study evaluates the efficacy of alpha-fetoprotein (AFP) response as a surrogate marker for determining recurrence-free survival (RFS) in patients with unresectable hepatocellular carcinoma (uHCC) who undergo salvage hepatectomy following conversion therapy with tyrosine kinase inhibitor (TKI) and anti-PD-1 antibody-based regimen.MethodsThis multicenter retrospective study included 74 patients with uHCC and positive AFP (>20 ng/mL) at diagnosis, who underwent salvage hepatectomy after treatment with TKIs and anti-PD-1 antibody-based regimens. The association between AFP response—defined as a ≥ 80% decrease in final AFP levels before salvage hepatectomy from diagnosis—and RFS post-hepatectomy was investigated.ResultsAFP responders demonstrated significantly better postoperative RFS compared to non-responders (P

Details

Language :
English
ISSN :
16643224 and 94467943
Volume :
15
Database :
Directory of Open Access Journals
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.94467943cf8482793fef503755d11c9
Document Type :
article
Full Text :
https://doi.org/10.3389/fimmu.2024.1308543